The goal of the BioASQ challenge is to engage researchers into creating cuttingedge biomedical information systems. Specifically, it aims at the promotion of systems and methodologies that are able to deal with a plethora of different tasks in the biomedical domain. This is achieved through the organization of challenges. The fifth challenge consisted of three tasks: semantic indexing, question answering and a new task on information extraction. In total, 29 teams with more than 95 systems participated in the challenge. Overall, as in previous years, the best systems were able to outperform the strong baselines. This suggests that state-of-the art systems are continuously improving, pushing the frontier of research.