One of the main challenges in biomedical text mining is the identification of terminology, which is a key factor for accessing and integrating the information stored in literature. Manual creation of biomedical terminologies cannot keep pace with the data that becomes available. Still, many of them have been used in attempts to recognise terms in literature, but their suitability for text mining has been questioned as substantial re-engineering is needed to tailor the resources for automatic processing. Several approaches have been suggested to automatically integrate and map between resources, but the problems of extensive variability of lexical representations and ambiguity have been revealed. In this paper we present a methodology to automatically maintain a biomedical terminological database, which contains automatically extracted terms, their mutual relationships, features and possible annotations that can be useful in text processing. In addition to TermDB, a database used for terminology management and storage, we present the following modules that are used to populate the database: TerMine (recognition, extraction and normalisation of terms from literature), AcroTerMine (extraction and clustering of acronyms and their long forms), AnnoTerm (annotation and classification of terms), and ClusTerm (extraction of term associations and clustering of terms).